Pediatric cns tumors pediatric oncology englisch gebundene ausgabe 5 oktober 2016 von nalin gupta herausgeber anuradha banerjee herausgeber daphne a haas kogan herausgeber 0 mehr alle formate und ausgaben anzeigen andere formate und ausgaben ausblenden. Pediatric cns tumors is a detailed review of childhood brain tumors that offers a biologically based perspective on their management for each tumor type epidemiology pathological features clinical presentation diagnosis and treatment are discussed particular emphasis is placed on the provision of treatment algorithms that reflect current best practice and controversies and therapeutic . As part of the special issue on pediatric neuro oncology this article will focus on four of the rarer tumors in this spectrum including atypical teratoid rhabdoid tumors embryonal tumors with multilayered rosettes choroid plexus tumors and pleomorphic xanthoastrocytoma. Of 14 consecutive pediatric patients with recurrent low grade glioma n11 or high grade cns tumors n3 with map kinase pathway mutations patients received trametinib as monotherapy n9 or in combination n5 with another antineoplastic agent nine patients 64 were progression free during treatment five patients showed a partial response while 4 had stable disease two patients 14
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